THE PHARMACOKINETICS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE ELDERLY

被引：16

作者：

FURLANUT, M ^{[1
]}

BENETELLO, P ^{[1
]}

机构：

[1] UNIV PADUA,INST NEUROL,I-35100 PADUA,ITALY

来源：

PHARMACOLOGICAL RESEARCH | 1990年 / 22卷 / 01期

关键词：

elderly; kinetics; tricyclic antidepressants;

D O I：

10.1016/1043-6618(90)90739-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding WAS) is not sufficiently developed. The present paper briefly reviews the available data on amitriptyline, nortriptyline, protriptyline, imipramine, desipramine and clomipramine kinetics in the elderly. © 1990 The Italian Pharmacological Society.

引用

页码：15 / 25

页数：11

共 104 条

[1]

ABERNETHY DR, 1985, J PHARMACOL EXP THER, V232, P183

[2] AGE EFFECTS ON ALPHA-1-ACID GLYCOPROTEIN CONCENTRATION AND IMIPRAMINE PLASMA-PROTEIN BINDING [J].