AN OXYGEN DEPENDENCE IN CHROMIUM MUTAGENESIS

被引：46

作者：

SUGDEN, KD ^{[1
]}

BURRIS, RB ^{[1
]}

ROGERS, SJ ^{[1
]}

机构：

[1] MONTANA STATE UNIV,DEPT BIOCHEM,BOZEMAN,MT 59715

来源：

MUTATION RESEARCH | 1990年 / 244卷 / 03期

关键词：

Chromium; Oxygen dependence;

D O I：

10.1016/0165-7992(90)90135-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations. © 1990.

引用

页码：239 / 244

页数：6

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