ANTIENDOTHELIAL CELL ANTIBODIES IN PATIENTS WITH THE ANTIPHOSPHOLIPID SYNDROME

被引：73

作者：

CERVERA, R ^{[1
]}

KHAMASHTA, MA ^{[1
]}

FONT, J ^{[1
]}

RAMIREZ, G ^{[1
]}

DCRUZ, D ^{[1
]}

MONTALBAN, J ^{[1
]}

LOPEZSOTO, A ^{[1
]}

ASHERSON, RA ^{[1
]}

INGELMO, M ^{[1
]}

HUGHES, GRV ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA,SERV MED INTERNA GEN,VILLARROEL 170,E-08036 BARCELONA,SPAIN

来源：

AUTOIMMUNITY | 1991年 / 11卷 / 01期

关键词：

ENDOTHELIAL CELLS; ANTICARDIOLIPIN ANTIBODIES; THROMBOSIS;

D O I：

10.3109/08916939108994701

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antiendothelial cell antibodies (AECA) have been detected in 20 out of 30 patients (67% with thrombosis associated with antiphospholipid antibodies. Seven patients had systemic lupus erythematosus and 13 had the "primary" antiphospholipid syndrome. Seven patients had both lgG and IgM AECA, 9 had lgG AECA only, and 4 had only IgM AECA. None of 30 control patients with thrombotic events not related to antiphospholipid antibodies had a positive titre of AECA (P<0.001). No correlation between AECA, antinuclear antibodies, anti-dsDNA antibodies, anti-neutrophil cytoplasm antibodies, precipitating antibodies to soluble nuclear and cytoplasmic antigens or complement components was found. The possible role of these AECA in the pathogenesis of thrombotic events is discussed. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1 / 6

页数：6

共 27 条

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