P53 AND C-MYC EXPRESSION IN STAGE A1 PROSTATIC ADENOCARCINOMA - USEFUL PROGNOSTIC DETERMINANTS

被引:44
作者
FOX, SB
PERSAD, RA
ROYDS, J
KORE, RN
SILCOCKS, PB
COLLINS, CC
机构
[1] UNIV SHEFFIELD, SCH MED, DEPT PATHOL, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND
[2] UNIV SHEFFIELD, SCH MED, DEPT PUBL HLTH, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND
[3] BRISTOL ROYAL INFIRM & GEN HOSP, DEPT PATHOL, BRISTOL BS2 8HW, AVON, ENGLAND
[4] BRISTOL ROYAL INFIRM & GEN HOSP, DEPT UROL, BRISTOL BS2 8HW, AVON, ENGLAND
关键词
PROSTATIC NEOPLASMS; GENES; SUPPRESSOR; TUMOR; IMMUNOHISTOCHEMISTRY;
D O I
10.1016/S0022-5347(17)35533-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Forty-five stage A1 prostatic adenocarcinomas from patients with a mean age of 65 years were examined for p53 and c-myc expression to determine whether the presence or absence of these proteins could predict tumor behavior. Thirteen (6 of 45) and seventy-three percent (33 of 45) of cases were respectively p53 and c-myc positive. p53 expression was confined to the tumor cells, whereas c-myc immunoreactivity was present in both malignant and surrounding hyperplastic prostate. Statistical analysis showed that although p53 and c-myc expression were positively correlated, expression of neither nuclear protein was associated with a significantly worse survival (p53: p = 0.0791 exact two-tailed; c-myc: p = 0.738 exact two-tailed). These results suggest that while both p53 and c-myc may play a role in prostatic carcinogenesis, neither appears to identify patients who may benefit from treatment in stage A disease.
引用
收藏
页码:490 / 494
页数:5
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