CHOLESTEROL FEEDING INDUCES HYPERTRIGLYCERIDEMIA IN HAMSTERS AND INCREASES THE ACTIVITY OF THE MG2+-DEPENDENT PHOSPHATIDATE PHOSPHOHYDROLASE IN THE LIVER

被引：14

作者：

SESSIONS, VA

MARTIN, A

GOMEZMUNOZ, A

BRINDLEY, DN

SALTER, AM

机构：

[1] UNIV NOTTINGHAM, FAC AGR & FOOD SCI, DEPT APPL BIOCH & FOOD SCI, LOUGHBOROUGH LE12 5RD, LEICS, ENGLAND

[2] UNIV ALBERTA, DEPT BIOCHEM, EDMONTON T6G 2E1, ALBERTA, CANADA

[3] UNIV ALBERTA, LIPID & LIPOPROT RES GRP, EDMONTON T6G 2E1, ALBERTA, CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1166卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

CHOLESTEROL; DIET; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; PHOSPHATIDATE PHOSPHOHYDROLASE; TRIACYLGLYCEROL;

D O I：

10.1016/0005-2760(93)90103-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(1) Feeding increased cholesterol to hamsters resulted in a dose-dependent increase in cholesterol and triacylglycerol in very-low-density lipoprotein (VLDL), in serum non-esterified fatty acids and in the activity of the Mg2+-dependent phosphatidate phosphohydrolase in liver. (2) The effects of increasing dietary cholesterol by 0.12% (w/w) in addition to feeding fat (14%, w/w) were dependent upon the nature of the fat. Lard in the presence of 0.12% (w/w) cholesterol increased serum triacylglycerols as did olive oil. By contrast, sunflower oil did not cause a significant change in serum triacylglycerol concentrations. (3) There was a highly positive correlation between VLDL triacylglycerol and VLDL cholesterol concentrations suggesting that, at least in this model, there is a close relationship between hypertriglyceridaemia and hypercholesterolaemia.

引用

页码：238 / 243

页数：6

共 23 条

[1]

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[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] HORMONAL-REGULATION OF THE HEPATIC LOW-DENSITY-LIPOPROTEIN RECEPTOR AND THE CATABOLISM OF LOW-DENSITY LIPOPROTEINS - RELATIONSHIP WITH THE SECRETION OF VERY LOW-DENSITY LIPOPROTEINS [J].