BIOLOGICAL AND CHEMICAL INVESTIGATION OF DRAGONS BLOOD FROM CROTON SPECIES OF SOUTH-AMERICA .2. DITERPENES FROM CROTON-LECHLERI

被引：35

作者：

CAI, Y ^{[1
]}

CHEN, ZP ^{[1
]}

PHILLIPSON, JD ^{[1
]}

机构：

[1] UNIV LONDON, SCH PHARM, DEPT PHARMACOGNOSY, LONDON, ENGLAND

来源：

PHYTOCHEMISTRY | 1993年 / 32卷 / 03期

关键词：

CROTON-LECHLERI; EUPHORBIACEAE; DRAGONS BLOOD; SANGRE DE GRADO; DITERPENOIDS; CROLECHINOL; CROLECHINIC ACID; CLERODANE;

D O I：

10.1016/S0031-9422(00)95166-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chloroform extract of Croton lechleri sap was chemically examined, and the major constituents characterized by mass and NMR spectroscopy. In addition to a number of known compounds, such as 1,3,5-trimethoxybenzene, 2,4,6-trimethoxyphenol, 3,4-dimethoxyphenol, 3,4-dimethoxybenzyl alcohol, 4-hydroxyphenethyl alcohol and its acetate, sitosterol, sitosterol-beta-D-glucopyranoside and beta-sitostenone, four diterpenoids were isolated from Croton lechleri bark, and two of them were found to be novel compounds possessing a clerodane skeleton. Their structures were unequivocally elucidated by extensive use of NMR spectroscopy. They were termed as crolechinol and crolechinic acid, respectively. The presence of these diterpenoids as minor constituents in the sap was confirmed by TLC profiles and NMR spectra.

引用

页码：755 / 760

页数：6

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