INCLUSION COMPLEXATION OF LORAZEPAM WITH BETA-CYCLODEXTRIN

被引：16

作者：

SANGHAVI, NM

CHOUDHARI, KB

MATHARU, RS

VISWANATHAN, L

机构：

[1] Pharamaceutical Section, University Department of Chemical Technology Matunga, Bombay

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 06期

关键词：

D O I：

10.3109/03639049309062976

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of an inclusion complex of Lorazepam, a benzodiazepine antianxiety agent with beta -cyclodextrin is described. The inclusion compound was prepared by the homogeneous coprecipitation method in the molar ratio of 1:2 of the drug and beta -cyclodextrin respectively. The formation of inclusion complex was evaluated by UV spectral studies, IR studies, X-ray diffractometry, and Differential Thermal Analysis. The solubility and in-vitro drug release studies indicated that the complex form of the drug significantly increase the solubility and the dissolution rate compared to the free form. Tablets prepared with Lorazepam- beta -cyclodextrin complex also showed a significant increase in dissolution of the drug indicating that beta -cyclodextrin plays an important role in the solubilization of the drug.

引用

页码：701 / 712

页数：12

共 11 条

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