A MODEL FOR KINETICS OF MERCURY ELIMINATION

被引：10

作者：

CEMBER, H

机构：

[1] Technological Institute, Northwestern University, Evanston, Illinois

来源：

AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL | 1969年 / 30卷 / 04期

关键词：

D O I：

10.1080/00028896909343139

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A four-compartment model was postulated, consisting of long- and short-term compartments (the kidneys and liver, respectively) a tissue compartment (the balance of the body), and an excretion reservoir. Assuming first-order kinetics, differential equations were written describing the rate of change of mercury in each compartment following a single exposure; the equations were solved using numerical parameter values obtained from an earlier experiment with Hg(NO3)2. The model was tested by injecting rats with 203HgCl2 at dose levels of 25, 50, and 100 μg Hg/kg. Mercury retention, as measured by whole-body counting, and mercury elimination, as measured by analyses of urine and feces, agreed with predictions based on the model. © 1969, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：367 / &

共 12 条

[1]

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[2]

Brown J R, 1967, Med Serv J Can, V23, P786

[3]

CEMBER H, 1962, Am Ind Hyg Assoc J, V23, P304, DOI 10.1080/00028896209342872

[4]

DURBIN PW, 1957, U CALIFORNIA PUBLICA, V3, P7

[5]

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[6]

HAMILTON A, 1949, INDUSTRIAL TOXICOLOG, pCH5

[7]

HAMILTON A, CITED INDIRECTLY

[8] ABSORPTION + EXCRETION OF MERCURY IN MAN .6. SIGNIFICANCE OF MERCURY IN URINE [J].

JACOBS, MB ;

LADD, AC ;

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ARCHIVES OF ENVIRONMENTAL HEALTH, 1964, 9 (04) :454-+

[9]

RAMAZZINI B, 1953, MORBIS ARTIFICUM, P21

[10]

Rashevsky N., 1965, THEORETICAL MATH BIO, P36

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