INDUCTION OF CHARACTERISTIC CHROMOSOMAL-ABERRATIONS, PARTICULARLY X-TRISOMY, IN CULTURED HUMAN-LYMPHOCYTES TREATED BY OCHRATOXIN-A, A MYCOTOXIN IMPLICATED IN BALKAN ENDEMIC NEPHROPATHY

被引：32

作者：

MANOLOVA, Y

MANOLOV, G

PARVANOVA, L

PETKOVABOCHAROVA, T

CASTEGNARO, M

CHERNOZEMSKY, IN

机构：

[1] INT AGCY RES CANC, ENVIRONM CARCINOGENS & HOST FACTORS UNIT, 150 COURS ALBERT THOMAS, F-69372 Lyon, FRANCE

[2] BULGARIAN ACAD SCI, INST CELL BIOL & MORPHOL, BU-1040 SOFIA, BULGARIA

[3] BULGARIAN ACAD MED, NATL ONCOL CTR, BU-1156 SOFIA, BULGARIA

来源：

MUTATION RESEARCH | 1990年 / 231卷 / 02期

关键词：

Chromosomal aberrations; Endemic nephropathy; Kidney microsomes; Lymphocytes; cultured human; Ochratoxin A; Urinary tract tumor;

D O I：

10.1016/0027-5107(90)90021-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ochratoxin A (OA), a mycotoxin which induces nephropathy and kidney tumours in rats and mice, is a contaminant of food consumed by a population with a high incidence of endemic nephropathy (EN). It was therefore tested in vitro for its ability to induce chromosomal aberrations in human peripheral lymphocyts in a small number of subjects, in the presence or absence of a kidney microsomal metabolic activation system. OA was found to induce aberrations on X chromosomes of similar types of those previously detected in lymphocytes from patients suffering from endemic nephropathy. © 1990.

引用

页码：143 / 149

页数：7

共 18 条

[1]

BENDELE AM, 1985, J NATL CANCER I, V75, P733

[2]

BOORMAN G, 1988, NIH882813 NAT TOX PR

[3]

CASTEGNARO M, 1987, CANCER RES, V47, P3608

[4] GEOGRAPHIC CORRELATION BETWEEN OCCURRENCE OF ENDEMIC NEPHROPATHY AND URINARY-TRACT TUMORS IN VRATZA DISTRICT, BULGARIA [J].

CHERNOZEMSKY, IN ;

STOYANOV, IS ;

PETKOVABOCHAROVA, TK ;

NICOLOV, IG ;

DRAGANOV, IV ;

STOICHEV, II ;

TANCHEV, Y ;

NAIDENOV, D ;

KALCHEVA, ND .

INTERNATIONAL JOURNAL OF CANCER, 1977, 19 (01) :1-11

[5] GENOTOXICITY OF OCHRATOXIN-A IN MICE - DNA SINGLE-STRAND BREAK EVALUATION IN SPLEEN, LIVER AND KIDNEY [J].

CREPPY, EE ;

KANE, A ;

DIRHEIMER, G ;

LAFARGEFRAYSSINET, C ;

MOUSSET, S ;

FRAYSSINET, C .

TOXICOLOGY LETTERS, 1985, 28 (01) :29-35

[6] GENETIC TOXICOLOGY OF ETHYLENEDIAMINETETRAACETIC ACID (EDTA) [J].

HEINDORFF, K ;

AURICH, O ;

MICHAELIS, A ;

RIEGER, R .

MUTATION RESEARCH, 1983, 115 (02) :149-173

[7]

HIETANEN E, 1986, DRUG METAB DISPOS, V14, P118

[8] OCHRATOXIN-A IN HUMAN-BLOOD AND BALKAN ENDEMIC NEPHROPATHY [J].

HULT, K ;

PLESTINA, R ;

HABAZINNOVAK, V ;

RADIC, B ;

CEOVIC, S .

ARCHIVES OF TOXICOLOGY, 1982, 51 (04) :313-321

[9]

KROGH P, 1977, ACTA PATH MICRO IM B, V85, P238

[10]

KROGH P, 1982, ENV CARCINOGENS SELE, V5, P247

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