ABLATION OF MURINE JEJUNAL CRYPTS BY ALKYLATING-AGENTS

被引：19

作者：

MOORE, JV ^{[1
]}

机构：

[1] HOLT RADIUM INST,MANCHESTER M20 9BX,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1979年 / 39卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/bjc.1979.28

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gut microcolony assay has been used to measure damage to intestinal crypts by single and split doses of 3 alkylating agents: mechlorethamine hydrochloride (HN2), bis-chloroethyl-nitrosourea (BCNU) and isopropyl methane sulphonate (IMS). The single-dose survival curves for whole crypts were distinguished by extrapolation numbers (30, 176 and 1-5 respectively) that were lower than most previously published values for assay by irradiation. Significant sparing of crypts occurred when doses of HN2 or BCNU, but not IMS, were given in 2 equal fractions separated by more than 2 h. Deduced D0 values for those cells from which crypts regenerate were 1-9 mg/kg HN2, 19 mg/kg BCNU and 487 mg/kg IMS. © 1979, The British Empire Cancer Campaign for Research. All rights reserved.

引用

页码：175 / 181

页数：7

共 20 条

[1] PROLIFERATIVE STATUS OF INTESTINAL EPITHELIAL CLONOGENIC CELLS - SENSITIVITY TO S PHASE SPECIFIC CYTOTOXIC AGENTS [J].