REBOUND INSOMNIA - POTENTIAL HAZARD FOLLOWING WITHDRAWAL OF CERTAIN BENZODIAZEPINES

被引：179

作者：

KALES, A ^{[1
]}

SCHARF, MB ^{[1
]}

KALES, JD ^{[1
]}

SOLDATOS, CR ^{[1
]}

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT PHARMACOL,CTR SLEEP RES & TREATMENT,HERSHEY,PA 17033

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1979年 / 241卷 / 16期

关键词：

D O I：

10.1001/jama.241.16.1692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Five benzodiazepine drugs (diazepam, flunitrazepam, flurazepam hydrochloride, nitrazepam, and triazolam) were evaluated separately in 15 sleep laboratory studies. Rebound insomnia, a worsening of sleep compared with baseline, occurred following withdrawal of triazolam, nitrazepam, and flunitrazepam after they had been given in only single, nightly doses for short periods. The rebound insomnia was attributed to the short and intermediate half-lives of these drugs. Diazepam and flurazepam, which have longer half-lives, did not cause rebound insomnia on withdrawal. Rebound insomnia may play a role in the development of hypnotic drug dependence with shorter-acting benzodiazepine drugs. (JAMA 241:1692-1695, 1979). © 1979, American Medical Association. All rights reserved.

引用

页码：1692 / 1695

页数：4

共 20 条

[1] NITRAZEPAM - LASTINGLY EFFECTIVE BUT TROUBLE ON WITHDRAWAL [J].