CENTRALLY ADMINISTERED NEUROTENSIN - ACTIVITY IN THE JULOU-COURVOISIER MUSCLE-RELAXATION TEST IN MICE

被引：57

作者：

OSBAHR, AJ ^{[1
]}

NEMEROFF, CB ^{[1
]}

MANBERG, PJ ^{[1
]}

PRANGE, AJ ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT PHARMACOL,PROGRAM NEUROBIOL,CHAPEL HILL,NC 27514

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 54卷 / 03期

关键词：

Neuroleptic; Neurotensin; Peptides; Thyrotropin-releasing hormone;

D O I：

10.1016/0014-2999(79)90090-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents. © 1979.

引用

页码：299 / 302

页数：4

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