USE OF SLIME DISPERSANTS TO PROMOTE ANTIBIOTIC PENETRATION THROUGH THE EXTRACELLULAR POLYSACCHARIDE OF MUCOID PSEUDOMONAS-AERUGINOSA

被引：34

作者：

GORDON, CA ^{[1
]}

HODGES, NA ^{[1
]}

MARRIOTT, C ^{[1
]}

机构：

[1] BRIGHTON POLYTECH,DEPT PHARM,PHARMACEUT SCI RES GRP,BRIGHTON BN2 4GJ,E SUSSEX,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 06期

关键词：

D O I：

10.1128/AAC.35.6.1258

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Agents with the potential to reduce Pseudomonas aeruginosa alginate viscosity (slime dispersants) were shown to promote the diffusion of antipseudomonal antibiotics through alginate but were more effective in facilitating the diffusion of gentamicin than that of ceftazidime. EDTA increased the diffusion rates of these antibiotics by factors of 4.0 and 1.5, respectively, although sodium chloride significantly reduced viscosity and enhanced gentamicin diffusion.

引用

页码：1258 / 1260

页数：3

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