HUMAN CCAAT DISPLACEMENT PROTEIN IS HOMOLOGOUS TO THE DROSOPHILA HOMEOPROTEIN, CUT

被引：197

作者：

NEUFELD, EJ

SKALNIK, DG

LIEVENS, PMJ

ORKIN, SH

机构：

[1] CHILDRENS HOSP MED CTR,DIV HEMATOL ONCOL,300 LONGWOOD AVE,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PEDIAT,BOSTON,MA 02115

[3] HOWARD HUGHES MED INST,BOSTON,MA 02115

[4] INDIANA UNIV,JAMES WHITCOMB RILEY HOSP CHILDREN,SCH MED,WELLS RES CTR,INDIANAPOLIS,IN 46223

来源：

NATURE GENETICS | 1992年 / 1卷 / 01期

关键词：

D O I：

10.1038/ng0492-50

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda-gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.

引用

页码：50 / 55

页数：6

共 37 条

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