CLINICAL SIGNS AND LABORATORY MARKERS IN PREDICTING PROGRESSION TO AIDS IN HIV-1 INFECTED PATIENTS

被引:34
作者
MORFELDTMANSON, L
BOTTIGER, B
NILSSON, B
VONSTEDINGK, LV
机构
[1] STOCKHOLM CTY COUNCIL, DEPT BACTERIOL, CENT MICROBIOL LAB, STOCKHOLM, SWEDEN
[2] NATL BACTERIOL LAB, DEPT IMMUNOL, S-10521 STOCKHOLM, SWEDEN
[3] RADIUMHEMMET, DEPT CANC EPIDEMIOL & BIOSTAT, STOCKHOLM, SWEDEN
关键词
D O I
10.3109/00365549109075092
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In a prospective longitudinal study 89 men with HIV-1 infection were observed for a mean time of 51 months with regard to clinical signs and laboratory findings predictive of progression to AIDS/opportunistic infection (OI). In a bivariate regression analysis the clinical signs showing a significant relation to AIDS development were: dermatitis of the face, yellow toe nail changes, hairy leukoplakia and oral candidiasis. The laboratory findings significantly associated with progression to AIDS were: decrease of the relative and absolute number of CD4 lymphocytes, decrease of the CD4/CD8 ratio, HIV p24 antigenaemia, lack of anti-HIV p24, elevated erythrocyte sedimentation rate, anaemia and elevated serum-beta-2-microglobulin. The relative number (%) of CD4 cells was found superior to the absolute number and the CD4/CD8 ratio. In a multivariate regression analysis decrease of CD4 lymphocytes and lack of anti-HIV p24 were independently associated with subsequent AIDS/OI development.
引用
收藏
页码:443 / 449
页数:7
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