DETERMINATION OF BIFUNCTIONAL COMPOUNDS .6. COMPARISON OF ELECTRON-CAPTURING BORONIC ACIDS FOR THE SELECTIVE ANALYSIS OF BIFUNCTIONAL COMPOUNDS

The preparation and chromatographic properties of 2,6-dichlorobenzeneboronic, 2,4,6-trichlorobenzeneboronic and 3,5-di(trifluoromethyl)benzeneboronic acids are described. These reagents are compared with seven other electron-capturing boronic acids on the basis of their range of application, relative volatility, electron-capture sensitivity and derivative stability to establish some criteria for the selection of the most useful reagents. It is proposed that the four boronic acids 3,5-di(trifluoromethyl)benzeneboronic, 2,4-dichlorobenzeneboronic, 4-bromobenzeneboronic and 4-iodobutaneboronic acid are sufficient to meet the needs of most analytical problems. © 1979.