FUNCTIONAL BRAIN MR-IMAGING BASED ON BOLUS TRACKING WITH A FAST T-2-ASTERISK-SENSITIZED GRADIENT-ECHO METHOD

被引：39

作者：

MOONEN, CTW

BARRIOS, FA

ZIGUN, JR

GILLEN, J

LIU, GY

SOBERING, G

SEXTON, R

WOO, J

FRANK, J

WEINBERGER, DR

机构：

[1] In Vivo NMR Research Center, National Institutes of Health, Bethesda

[2] Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda

[3] Clinical Brain Disorders Branch, NIMH, Washington

[4] Pittsburgh NMR Institute, Pittsburgh

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 03期

关键词：

MRI; BLOOD; VOLUME; BLOOD FLOW; DYNAMICS; BLOOD MR STUDIES;

D O I：

10.1016/0730-725X(94)92530-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Dynamic physiological scanning, based on temporary changes in local field homogeneity during the passage of a contrast agent bolus, has been performed hitherto with echo-planar imaging (EPI) or conventional gradient-recalled techniques (FLASH). Here, it is shown that the T-2* sensitivity of conventional FLASH techniques can be improved drastically on a conventional whole body instrument by delaying the gradient-echo until the subsequent TR-period without increasing total imaging time. Examples are given for a full k-space matrix (128 x 256) obtained within 2 s with a TE of 25 ms, resulting in images free of artifacts. The method is applied to bolus tracking through the brain of healthy volunteers during visual stimulation and in the dark. An average increase of regional cerebral blood volume (rCBV) in the visual cortex of 10.9% (n = 9, p =.001) was found.

引用

页码：379 / 385

页数：7

共 19 条

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