MICROGLIA EXPRESS THE TYPE-2 PLASMINOGEN-ACTIVATOR INHIBITOR IN THE BRAIN OF CONTROL SUBJECTS AND PATIENTS WITH ALZHEIMERS-DISEASE

被引：43

作者：

AKIYAMA, H

IKEDA, K

KONDO, H

KATO, M

MCGEER, PL

机构：

[1] SOGA HOSP,ODAWARA 25002,JAPAN

[2] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER V6T 1W5,BC,CANADA

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

PLASMINOGEN ACTIVATOR INHIBITOR; ALZHEIMERS DISEASE; MICROGLIA; SERPIN; INFLAMMATION;

D O I：

10.1016/0304-3940(93)90899-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.

引用

页码：233 / 235

页数：3

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