TASK-DEPENDENT GENETIC INFLUENCES ON BEHAVIORAL RESPONSE OF MICE (MUS-MUSCULUS) TO ACETALDEHYDE

Employed acetaldehyde as a pharmacological agent in behavioral tests designed to assess genetic influences on response to the drug. When used as a poison in a conditioned taste aversion study with 200 male mice, acetaldehyde was more effective at inducing aversions in DBA/2J mice than in C57BL/6J mice. In another experiment, however, 6 C57 mice were more affected than were 6 DBA mice by acetaldehyde effects on loss of righting reflex. Implications for postulated genetic control of ethanol preference and neurosensitivity are discussed. (33 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved). © 1978 American Psychological Association.