A NOVEL FUNCTION OF THE TRANSFORMING DOMAIN OF E1A - REPRESSION OF AP-1 ACTIVITY

被引：149

作者：

OFFRINGA, R

GEBEL, S

VANDAM, H

TIMMERS, M

SMITS, A

ZWART, R

STEIN, B

BOS, JL

VANDEREB, A

HERRLICH, P

机构：

[1] KERNFORSCHUNGSZENTRUM KARLSRUHE GMBH,INST GENET & TOXIKOL,W-7500 KARLSRUHE 1,GERMANY

[2] UNIV KARLSRUHE,INST GENET,W-7500 KARLSRUHE 1,GERMANY

来源：

CELL | 1990年 / 62卷 / 03期

关键词：

D O I：

10.1016/0092-8674(90)90017-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenovirus E1a represses transcription of the collagenase gene via the phorbol ester-responsive element (collTRE). The mechanism involves inhibition of the trans-activating function of the transcription factor AP-1 without reduction of its synthesis and without any apparent change in DNA binding or composition. The ability of E1a to downmodulate AP-1 is a unique property among dominant oncogenes. This repression depends on conserved region 1, one of the transforming domains of E1a, indicating that it is an integral feature of adenovirus transformation. © 1990.

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页码：527 / 538

页数：12

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