THYROID AUTOANTIBODIES IN BLACK AND IN WHITE-CHILDREN AND ADOLESCENTS WITH TYPE-1 DIABETES-MELLITUS AND THEIR 1ST DEGREE RELATIVES

被引：54

作者：

BUREK, CL ^{[1
]}

ROSE, NR ^{[1
]}

GUIRE, KE ^{[1
]}

HOFFMAN, WH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 2-3期

关键词：

American blacks; American whites; Autoimmune thyroid disease; Genetic susceptibility; Thyroid autoantibodies; Type I diabetes mellitus;

D O I：

10.3109/08916939008993388

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic susceptibility is an important issue in understanding the mechanism of the autoimmune endocri-nopathies and in assessing the risk of these conditions in pediatric patients. To this end, we evaluated autoantibodies to thyroid antigens, thyroglobulin (TgA) and microsomal antigen (TMA), in white and in American black juvenile patients with Type I diabetes mellitus (DM) to determine the predictive value of thyroid autoantibodies for the development of autoimmune thyroid disease. Sera from 159 patients (77 black and 82 white) with Type I DM were evaluated. A greater number of whites (41/82 or 50% than blacks (12/72 or 16% had thyroid autoantibodies (p < 0.01). Fourteen patients (4 black and 10 white) exhibited hypothyroidism, and all had both TgA and TMA. Three patients (all black) had Graves' disease, one of whom had both TgA and TMA. Families of each racial group that had a diabetic child (proband) with thyroid autoantibodies (seropositive) or without thyroid autoantibodies (seronegative) were assessed for TgA and TMA as well as autoimmune thyroid disease. The prevalence of thyroid autoantibodies among siblings of seropositive probands was significantly greater than among the siblings of seronegative probands (p < 0.01). The white sibling population showed a closer association of thyroid autoantibody prevalence with increasing age (p < 0.05) than the blacks. Significantly more parents of probands than control parents exhibited thyroid autoantibodies (p < 0.01). The general pattern of inheritance of either racial group showed that if one or both parents had thyroid autoantibodies, their progeny developed a significantly higher prevalence of thyroid autoantibodies than those of the seronegative parents. While there was no increase in overt thyroid disease among siblings of seropositive probands. a risk of developing autoimmune thyroid disease is probably imparted to these siblings by virtue of the thyroid autoantibodies. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：157 / 167

页数：11

共 27 条

[1] Nerup J., Lernmark A., Autoimmunity in insulin-dependent diabetes mellitus, Am J Med, 70, pp. 135-141, (1981)
[2] Barbosa J., Chavers B., Dunsworth T., Michael A., Islet cell antibodies and histocompatibility antigens (HLA) in insulin-dependent diabetics and their first-degree relatives, Diabetes, 31, pp. 585-588, (1982)
[3] Srikanta S., Ganda O.P., Eisenbarth G.S., Soeldner J.S., Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type 1 diabetes mellitus, N Engl J Med, 308, pp. 322-325, (1983)
[4] Srikanta S., Ganda O.P., Rabizddeh A., Soeldner J.S., Eisenbarth G.S., First-degree relatives of patients with type I diabetes mellitus. Islet-cell antibodies and abnormal insulin secretion, N Engl J Med, 313, pp. 461-464, (1985)
[5] Landing B.H., Pettit M.D., Wiens R.L., Knowles H., Guest G.M., Antithyroid antibody and chronic thyroiditis in diabetes, J CIin Endocrinol Metab, 23, pp. 119-120, (1963)
[6] Hayles A.B., Kennedy R.L.J., Beahrs O.H., Woolner L.B., Exophthalmic goiter in children, J Clin Endocrinol Metab, 19, pp. 138-151, (1959)
[7] Regan J.F., Wilder R.M., Hyperthyroidism and diabetes, Arch Intern Med, 65, pp. 1116-1122, (1940)
[8] Solomon I., Blizzard R.M., Autoimmune disorders of endocrine glands, J Pediatr, 63, pp. 1021-1033, (1963)
[9] Nissley S.P., Drash A.L., Blizzard R.M., Sperling M., Childs B., Comparison of juvenile diabetics with positive and negative organ specific antibody titers. Evidence for genetic heterogeneity, Diabetes, 22, pp. 63-65, (1973)
[10] Fialkow P.J., Zavala C., Nielsen R., Thyroid autoimmunity: increased frequency in relatives of insulin-dependent diabetes patients, Ann Intern Med, 83, pp. 170-176, (1975)

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