THE ABSOLUTE-CONFIGURATION OF THE ENANTIOMERS OF 6-CHLORO-9-(4'-DIETHYLAMINO-1'-METHYLBUTYL)-AMINO-2-METHOXYACRIDINE (QUINACRINE)

被引：3

作者：

CRAIG, JC

LABELLE, B

OHNSORGE, U

机构：

[1] Department of Pharmaceutical Chemistry, University of California, San Francisco, California

来源：

CHIRALITY | 1991年 / 3卷 / 05期

关键词：

STEREOCHEMISTRY; QUINACRINE; ENANTIOMERS; ENANTIOSELECTIVITY; CIRCULAR DICHROISM;

D O I：

10.1002/chir.530030510

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Absolute configurations have been assigned to the enantiomers of the antimalarial drug quinacrine dihydrochloride. Condensation of (-)-(R)-4-amino-1-diethylaminopentane (from L-glutamic acid) with 6,9-dichloro-2-methoxyacridine gave (-)-(R)-6-chloro-9-(4'-diethylamino-1'-methylbutyl) amino-2-methoxyacridine [(-)-(R)-quinacrine] while (+)-(S)-quinacrine was obtained from the enantiomeric diamine.

引用

页码：436 / 437

页数：2

共 9 条

[1]

ACHESON RM, 1956, ACRIDINES, P373

[2]

ALBERT A, 1951, ACRIDINES, P177

[3] THE RESOLUTION OF ATABRINE DIHYDROCHLORIDE [J].