C-11-LABELED OCTANAL AND BENZALDEHYDE

被引：24

作者：

TANG, DY

LIPMAN, A

MEYER, GJ

WAN, CN

WOLF, AP

机构：

[1] Department of Chemistry, Brookhaven National Laboratory, Upton, New York

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 03期

关键词：

!sup]11[!/sup]C‐benzaldehyde; !sup]11[!/sup]C‐octanal; !sup]11[!/sup]C‐organoboranes;

D O I：

10.1002/jlcr.2580160309

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of octanal and benzaldehyde, labeled with 11C in the carbonyl position, is reported. Octanal was prepared via an insertion reaction of 11CO into the boroncarbon bond of B‐heptyl‐9‐BBN, followed by oxidative hydrolysis. Benzaldehyde was synthesized by the reaction of phenyl magnesium bromide with 11CO2, and subsequent reduction of the labeled benzoic acid to benzylalcohol which was then oxidized to the final product by CrO2Cl2. Both aldehydes were purified via GLPC, leading to radiochemical purities of > 99.5% in each case. The radiochemical yield for octanal and benzaldehyde was 30 ± 5% and 15 ± 5%, respectively. The overall synthesis time was 50 ± 10 min for each compound. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：435 / 440

页数：6

共 24 条

[1] REACTION OF B-ALKYL-9-BORABICYCLO[3.3.1]NONANES WITH CARBON MONOXIDE IN PRESENCE OF LITHIUM TRIMETHOXYALUMINOHYDRIDE . A CONVENIENT PROCEDURE FOR CONVERSION OF OLEFINS INTO ALDEHYDES VIA HYDROBORATION [J].