ALDOSTERONE ANTAGONISTS .4. SYNTHESIS AND ACTIVITIES OF STEROIDAL 6,6-ETHYLENE-15,16-METHYLENE 17-SPIROLACTONES

被引：12

作者：

NICKISCH, K ^{[1
]}

BEIER, S ^{[1
]}

BITTLER, D ^{[1
]}

ELGER, W ^{[1
]}

LAURENT, H ^{[1
]}

LOSERT, W ^{[1
]}

NISHINO, Y ^{[1
]}

SCHILLINGER, E ^{[1
]}

WIECHERT, R ^{[1
]}

机构：

[1] SCHERING AG,RES LABS,BERGKAMEN,GERMANY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 08期

关键词：

D O I：

10.1021/jm00112a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several steroidal 6,6-ethylene-15,16-methylene 17-spirolactones were synthesized to find new progestogens that exhibit both progestational and antimineralocorticoidal activities. The influence of substituents in the 10- and 13-position of the steroidal framework on both properties was investigated. It was found that only compound 12, carrying methyl groups at the 10- and 13-positions, possesses high progestational and antimineralocorticoidal activity.

引用

页码：2464 / 2468

页数：5

共 22 条

[1] DETECTION AND COMPARATIVE-EVALUATION OF ALDOSTERONE ANTAGONISTS IN GLUCOCORTICOID-TREATED, ADRENALECTOMIZED RATS [J].