EXPRESSION OF SEQUENCES HOMOLOGOUS TO HTLV-I TAX GENE IN THE LABIAL SALIVARY-GLANDS OF JAPANESE PATIENTS WITH SJOGRENS-SYNDROME

被引：68

作者：

SUMIDA, T ^{[1
]}

YONAHA, F ^{[1
]}

MAEDA, T ^{[1
]}

KITA, Y ^{[1
]}

IWAMOTO, I ^{[1
]}

KOIKE, T ^{[1
]}

YOSHIDA, S ^{[1
]}

机构：

[1] HOKKAIDO UNIV,SCH MED,SAPPORO,HOKKAIDO 060,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 04期

关键词：

D O I：

10.1002/art.1780370415

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To address the question of whether the human T cell leukemia virus type I (HTLV-I) gene is associated with the. etiology of Sjogren's syndrome (SS). Methods. RNA expression of HTLV-I gag, pol, env, and tax genes in labial salivary glands (LSGs) from SS patients who were seronegative for antibodies to HTLV-I was examined using reverse transcription and polymerase chain reaction techniques. Results. The HTLV-I tax gene, but not the HTLV-I gag, pol, or env genes, was detected in LSG samples from 4 of 14 patients (29%). The nucleotide sequences of the HTLV-I pXIV region in these 4 patients' LSGs showed 100% homology to the HTLV-I pXIV gene from the MT-2 cell line. Conclusion. These findings suggest that products encoding sequences homologous to the HTLV-I pXIV gene in SS patients' LSGs might be candidates for self-antigen and/or lead to activation of autoreactive T lymphocytes through trans-acting transcriptional activation.

引用

页码：545 / 550

页数：6

共 24 条

[1]

ARAI N, 1989, J IMMUNOL, V142, P274

[2] HUMAN T-CELL LYMPHOTROPIC VIRUS (HTLV)-RELATED ENDOGENOUS SEQUENCE, HRES-1, ENCODES A 28-KDA PROTEIN - A POSSIBLE AUTOANTIGEN FOR HTLV-I GAG-REACTIVE AUTOANTIBODIES [J].