A NEW HIGH-FREQUENCY POLYMORPHISM IN THE HER-2/NEU ONCOGENE IN NORMAL TISSUE AND BREAST-TUMORS

被引：7

作者：

BRISCOE, WT

RAY, DB

AIRHART, JL

RATLIFF, AL

SHOCKLEY, EA

WHETSELL, L

SCHAEFER, FV

WILLIAMS, RM

机构：

[1] CANC TREATMENT RES FDN,TULSA,OK 74137

[2] CHILDRENS MED CTR,HA CHAPMAN RES INST,TULSA,OK 74135

[3] NORTHWESTERN UNIV,SCH MED,CHICAGO,IL 60606

[4] CANC TREATMENT CTR AMER,NORTHBROOK,IL 60062

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 28卷 / 01期

关键词：

BASE SEQUENCE; HER-2/NEU; INTRON; ONCOGENE; POLYMORPHISM;

D O I：

10.1007/BF00666355

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The HER-2/neu (erbB-2) oncogene, if amplified and/or overexpressed in breast and ovarian cancers, is associated with a poor prognosis. Employing direct DNA sequencing, we have discovered and sequenced an 80 base pair intron from human placenta which contains an A to G polymorphism. This polymorphism lends itself to restriction fragment length polymorphism analysis of the PCR product spanning this intron. All three genotypes, homozygous A, heterozygous, and homozygous G appear in normal control populations and breast tumors. Also, no difference was seen between the polymorphic form found in five breast cancers and the corresponding normal tissue.

引用

页码：45 / 49

页数：5

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