AN IONIZING RADIATION-SENSITIVE MUTANT OF CHO CELLS - IRS-20 .2. DOSE-RATE EFFECTS AND CELLULAR-RECOVERY PROCESSES

被引：40

作者：

STACKHOUSE, MA ^{[1
]}

BEDFORD, JS ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT RADIOL HLTH SCI,FT COLLINS,CO 80523

来源：

RADIATION RESEARCH | 1993年 / 136卷 / 02期

关键词：

D O I：

10.2307/3578618

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An ionizing radiation-sensitive mutant of CHO cells, irs-20, irradiated in plateau-phase cultures showed a complete lack of a dose-rate effect, i.e., there was no reduction in cell killing per unit dose as the dose rate was lowered from 0.75 Gy/min to 0.06 Gy/h. No measurable repair of potentially lethal damage or sublethal damage was evident for irs-20 cells in the G1 phase of the cell cycle. During S phase, irs-20 cells showed repair of sublethal damage similar to that for the wild-type cells.

引用

页码：250 / 254

页数：5

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