OPPOSITE EFFECTS OF CHOLINERGIC AGENTS AND BENZODIAZEPINE RECEPTOR LIGANDS IN A PASSIVE-AVOIDANCE TASK IN RATS

被引：19

作者：

ANGLADE, F

BIZOT, JC

DODD, RH

BAUDOIN, C

CHAPOUTHIER, G

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] UNIV PARIS 13,LEEC,F-93430 VILLETANEUSE,FRANCE

[3] UNIV PARIS 05,UFR BIOMED,GENET NEUROGENET & COMPORTEMENT LAB,F-75006 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 182卷 / 02期

关键词：

MEMORY; CHOLINERGIC AGENT; BENZODIAZEPINE; PASSIVE AVOIDANCE; RAT;

D O I：

10.1016/0304-3940(94)90808-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Benzodiazepine (Bzd) agonist, diazepam (Dzp) and inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM); acetylcholinesterase inhibitor, physostigmine (Physo) and muscarinic antagonist, scopolamine (Scope), were investigated for their mnesic effect in a passive avoidance (PA) task in rats. Impairments were observed after Dzp- and/or Scope-pretraining treatments. Physo was without effect but antagonized the Dzp-induced impairments. beta-CCM enhanced acquisition and antagonized the Scopo-induced impairing effect. All these drugs had no effect in posttraining administration.

引用

页码：247 / 250

页数：4

共 19 条

[1] MODIFICATION OF TREMORIGENIC ACTIVITY OF PHYSOSTIGMINE [J].