EFFECT OF CALCITONIN, ELEVATED CALCIUM AND EXTRACELLULAR MATRICES ON SUPEROXIDE ANION PRODUCTION BY RAT OSTEOCLASTS

被引：21

作者：

DATTA, HK

MANNING, P

RATHOD, H

MCNEIL, CJ

机构：

来源：

EXPERIMENTAL PHYSIOLOGY | 1995年 / 80卷 / 05期

关键词：

D O I：

10.1113/expphysiol.1995.sp003880

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The electrochemical determination of superoxide anion generation by isolated mammalian osteoclasts was carried out by employing cytochrome c, immobilized at a surface-modified gold electrode. Osteoclasts cultured on bone generated 15-fold more superoxide anions than cells plated on plastic. Superoxide anion production by osteoclasts cultured on bone was almost completely abolished by salmon calcitonin, and partially abolished following exposure to elevated extracellular calcium. We therefore conclude that osteoclast activity is influenced substantially by the extracellular matrix.

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页码：713 / 719

页数：7

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