ARE HISTAMINE H-2-RECEPTOR DEPRESSIONS OF NEURONAL-ACTIVITY IN TISSUE-CULTURES FROM RAT HYPOTHALAMUS MEDIATED THROUGH CYCLIC ADENOSINE-MONOPHOSPHATE

被引：12

作者：

GELLER, HM

机构：

[1] Department of Pharmacology, CMDNJ-Rutgers Medical School, Piscataway

来源：

NEUROSCIENCE LETTERS | 1979年 / 14卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0304-3940(79)95342-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Iontophoretic application of histamine H2-agonists depressed spontaneous firing of tuberal hypothalamic neurons in tissue culture. Perfusion with inhibitors of cyclic nucleotide phosphodiesterase increased the strength of these depressions, which persisted during perfusion with Ca2+-free medium. These results support a role of cyclic AMP as a mediator of histamine H2-elicited depressions of neuronal activity. © 1979.

引用

页码：49 / 53

页数：5

共 18 条

[1] COMPARISON OF EFFECTS OF NORADRENALINE AND HISTAMINE WITH CYCLIC-AMP ON BRAIN-STEM NEURONS [J].