TETANUS TOXIN PRODUCES NEURONAL LOSS AND A REDUCTION IN GABA-A BUT NOT GABA-B BINDING-SITES IN RAT HIPPOCAMPUS

被引：15

作者：

BAGETTA, G

KNOTT, C

NISTICO, G

BOWERY, NG

机构：

[1] UNIV LONDON,DEPT PHARMACOL,29-39 BRUNSWICK SQ,LONDON WC1N 1AX,ENGLAND

[2] UNIV REGGIO CALABRIA,FAC MED & SURG CATANZARO,REGGIO CALABIA,ITALY

来源：

NEUROSCIENCE LETTERS | 1990年 / 109卷 / 1-2期

关键词：

Autoradiography; Hippocampal neurodegeneration; Tetanus toxin; γ-Aminobutyric acid-A binding site; γ-Aminobutyric acid-B binding site;

D O I：

10.1016/0304-3940(90)90529-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropathological effects of tetanus toxin, microinjected in the rat CA1 hippocampal area, were studied by using a microscopical and autoradiographical approach. Tetanus toxin produced a dose- and time-dependent neuronal loss in the CA1 area accompanied by a reduction in the binding of γ-[3H]aminobutyric acid ([3H]GABA) to GABAA but not GABAB sites in the pyramidal cell layer. © 1990.

引用

页码：7 / 12

页数：6

共 21 条

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