PRODUCTION OF IL-6 (BSF-2/IFN BETA-2) BY MONONUCLEAR-CELLS IN PREMATURE AND TERM INFANTS

被引：16

作者：

SAITO, S ^{[1
]}

SAITO, M ^{[1
]}

KATO, Y ^{[1
]}

MARUYAMA, M ^{[1
]}

MORIYAMA, I ^{[1
]}

ICHIJO, M ^{[1
]}

机构：

[1] HABIKINO HOSP,DEPT OBSTET & GYNECOL,HABIKINO,OSAKA 583,JAPAN

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1990年 / 17卷 / 01期

关键词：

IgM; interleukin; 6; mononuclear cells; premature infants; premature rupture of the membrane;

D O I：

10.1016/0165-0378(90)90036-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production of interleukin 6 (IL-6) was examined in premature neonates (48 cases, including 3 miscarried fetuses) and fullterm neonates (20 cases). The IL-6 production by mononuclear cells was measured after stimulation with Staphylococcus aureus Cowan Strain I (SAC), phytohemagglutinin (PHA) or lipopolysaccharide (LPS). The production in full-term neonates was similar to that in healthy adults, whereas it was significantly lower in premature neonates without premature rupture of the membrane (PROM). However, in premature infants with PROM a normal level of IL-6 production was observed in mononuclear cells stimulated with SAC, PHA and LPS. Furthermore, there was a positive correlation between the IgM concentration in the cord serum and IL-6 production by LPS-stimulated mononuclear cells. © 1990.

引用

页码：17 / 26

页数：10

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