PRODUCTION OF IL-6 (BSF-2/IFN BETA-2) BY MONONUCLEAR-CELLS IN PREMATURE AND TERM INFANTS

被引:16
作者
SAITO, S [1 ]
SAITO, M [1 ]
KATO, Y [1 ]
MARUYAMA, M [1 ]
MORIYAMA, I [1 ]
ICHIJO, M [1 ]
机构
[1] HABIKINO HOSP,DEPT OBSTET & GYNECOL,HABIKINO,OSAKA 583,JAPAN
关键词
IgM; interleukin; 6; mononuclear cells; premature infants; premature rupture of the membrane;
D O I
10.1016/0165-0378(90)90036-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The production of interleukin 6 (IL-6) was examined in premature neonates (48 cases, including 3 miscarried fetuses) and fullterm neonates (20 cases). The IL-6 production by mononuclear cells was measured after stimulation with Staphylococcus aureus Cowan Strain I (SAC), phytohemagglutinin (PHA) or lipopolysaccharide (LPS). The production in full-term neonates was similar to that in healthy adults, whereas it was significantly lower in premature neonates without premature rupture of the membrane (PROM). However, in premature infants with PROM a normal level of IL-6 production was observed in mononuclear cells stimulated with SAC, PHA and LPS. Furthermore, there was a positive correlation between the IgM concentration in the cord serum and IL-6 production by LPS-stimulated mononuclear cells. © 1990.
引用
收藏
页码:17 / 26
页数:10
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