OPPOSITE EFFECTS OF ENDOTHELIN-1 AND BIG-ENDOTHELIN-(1-39) ON RENAL-FUNCTION IN RATS

被引：26

作者：

HOFFMAN, A

GROSSMAN, E

KEISER, HR

机构：

[1] Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, Bethesda

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 182卷 / 03期

关键词：

Endothelin; Renal blood flow; Renal function;

D O I：

10.1016/0014-2999(90)90064-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1. © 1990.

引用

页码：603 / 606

页数：4

共 7 条

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FIRTH JD, 1988, LANCET, V2, P1179

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