OPPOSITE EFFECTS OF ENDOTHELIN-1 AND BIG-ENDOTHELIN-(1-39) ON RENAL-FUNCTION IN RATS

被引:26
作者
HOFFMAN, A
GROSSMAN, E
KEISER, HR
机构
[1] Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, Bethesda
关键词
Endothelin; Renal blood flow; Renal function;
D O I
10.1016/0014-2999(90)90064-D
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1. © 1990.
引用
收藏
页码:603 / 606
页数:4
相关论文
共 7 条
[1]  
FIRTH JD, 1988, LANCET, V2, P1179
[2]   ENDOTHELIN IS A POTENT SECRETAGOGUE FOR ATRIAL NATRIURETIC PEPTIDE IN CULTURED RAT ATRIAL MYOCYTES [J].
FUKUDA, Y ;
HIRATA, Y ;
YOSHIMI, H ;
KOJIMA, T ;
KOBAYASHI, Y ;
YANAGISAWA, M ;
MASAKI, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (01) :167-172
[3]   ENDOTHELIN INDUCES AN INITIAL INCREASE IN CARDIAC-OUTPUT ASSOCIATED WITH SELECTIVE VASODILATION IN RATS [J].
HOFFMAN, A ;
GROSSMAN, E ;
OHMAN, KP ;
MARKS, E ;
KEISER, HR .
LIFE SCIENCES, 1989, 45 (03) :249-255
[4]   PUTATIVE PRECURSORS OF ENDOTHELIN HAVE LESS VASOCONSTRICTOR ACTIVITY INVITRO BUT A POTENT PRESSOR EFFECT INVIVO [J].
KASHIWABARA, T ;
INAGAKI, Y ;
OHTA, H ;
IWAMATSU, A ;
NOMIZU, M ;
MORITA, A ;
NISHIKORI, K .
FEBS LETTERS, 1989, 247 (01) :73-76
[5]   INTEGRATED CARDIAC, RENAL, AND ENDOCRINE ACTIONS OF ENDOTHELIN [J].
MILLER, WL ;
REDFIELD, MM ;
BURNETT, JC .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (01) :317-320
[6]   A NOVEL POTENT VASOCONSTRICTOR PEPTIDE PRODUCED BY VASCULAR ENDOTHELIAL-CELLS [J].
YANAGISAWA, M ;
KURIHARA, H ;
KIMURA, S ;
TOMOBE, Y ;
KOBAYASHI, M ;
MITSUI, Y ;
YAZAKI, Y ;
GOTO, K ;
MASAKI, T .
NATURE, 1988, 332 (6163) :411-415
[7]   ENDOTHELIN, A PEPTIDE INHIBITOR OF NA+-K+-ATPASE IN INTACT RENAL TUBULAR EPITHELIAL-CELLS [J].
ZEIDEL, ML ;
BRADY, HR ;
KONE, BC ;
GULLANS, SR ;
BRENNER, BM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06) :C1101-C1107