PHENOTYPIC AND GENETIC-CHARACTERIZATION OF A UNIQUE LYMPHOCYTE-B DEFICIENCY IN STRAIN A/WYSNJ MICE

被引:83
作者
MILLER, DJ [1 ]
HAYES, CE [1 ]
机构
[1] UNIV WISCONSIN,COLL AGR & LIFE SCI,DEPT BIOCHEM,420 HENRY MALL,MADISON,WI 53706
关键词
D O I
10.1002/eji.1830210506
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The elucidation of B lymphocyte development has been partially achieved through genetic models such as the X-linked immunodeficiency (xid) mutation. We discovered a unique B lymphocyte developmental defect in strain A/WySnJ mice. We used single- and two-color flow cytometry to analyze lymphocytes from A/J and A/WySnJ mice. Adult A/WySnJ mice had asevere B cell deficiency, which was apparent in the spleen, lymph nodes, peritoneum and peripheral blood, compared to adult A/J mice. An ontogeny study revealed that a developmental defect, inhibiting B lymphocyte maturation or differentiation but not B lymphopoiesis, was responsible for the deficiency. This maturational defect blocked the production of B220hi/Ia(hi)/surface IgM(lo) B cells, and was manifested in the adult bone marrow and neonatal spleen, but not the adult spleen. Neither Ly-1 B cells nor peripheral T cells were apparently affected by the A/WySnJ defect. The B cell immunodeficiency segregated as an autosomal co-dominant trait in F1 and F2 mice. We propose that A/WySnJ mice have a novel genetic defect arresting B cell differentiation in adult bone marrow and neonatal spleen.
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页码:1123 / 1130
页数:8
相关论文
共 48 条
[1]   IDENTIFICATION IN ADULT BONE-MARROW OF PLURIPOTENT AND RESTRICTED STEM-CELLS OF MYELOID AND LYMPHOID SYSTEMS [J].
ABRAMSON, S ;
MILLER, RG ;
PHILLIPS, RA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 145 (06) :1567-1579
[2]  
Bailey DW, 1978, ORIGINS INBRED MICE, P197
[3]  
BAZIN H, 1986, METHOD ENZYMOL, V121, P638
[4]  
BERNING AK, 1980, J IMMUNOL, V124, P1875
[5]  
BIRD G, 1988, B LYMPHOCYTES HUMAN, P257
[6]  
BRUCE J, 1981, J IMMUNOL, V127, P2496
[7]   LIGAND-INDUCED DESENSITIZATION OF B-CELL MEMBRANE IMMUNOGLOBULIN-MEDIATED CA-2+ MOBILIZATION AND PROTEIN KINASE-C TRANSLOCATION [J].
CAMBIER, J ;
CHEN, ZZ ;
PASTERNAK, J ;
RANSOM, J ;
SANDOVAL, V ;
PICKLES, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (17) :6493-6497
[8]  
Cochran W.G, 1957, STAT METHODS, V6th ed
[9]  
Coffman R L, 1982, Immunol Rev, V69, P5
[10]   B220 - A B-CELL-SPECIFIC MEMBER OF THE T200 GLYCOPROTEIN FAMILY [J].
COFFMAN, RL ;
WEISSMAN, IL .
NATURE, 1981, 289 (5799) :681-683