T-CELL RECEPTOR CONSTANT BETA-CHAIN POLYMORPHISMS AND SUSCEPTIBILITY TO TYPE-1 DIABETES

被引：18

作者：

HIBBERD, ML ^{[1
]}

MILLWARD, BA ^{[1
]}

WONG, FS ^{[1
]}

DEMAINE, AG ^{[1
]}

机构：

[1] KINGS COLL,SCH MED & DENT,DEPT MED,DENMARK HILL,LONDON SE5 8RX,ENGLAND

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 10期

关键词：

T-CELL RECEPTOR; RFLP; DIABETIC COMPLICATIONS; IMMUNOGENETICS;

D O I：

10.1111/j.1464-5491.1992.tb01733.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several groups have previously shown that the T-cell receptor (TCR) constant-beta (Cbeta) chain locus is associated with susceptibility to Type 1 diabetes, although other studies have failed to show this. We have extended these studies by investigating 125 individuals with Type 1 diabetes and failed to confirm the significantly increased frequency of the 10;9.2 kb TCR-Cbeta/BgI-II genotype in our patient population. However, further analysis showed that the 10;9.2 kb TCR-Cbeta genotype was significantly increased in those patients with no microvascular complications after 20 years of diabetes compared to those patients with complications (proteinuria, overt neuropathy, and moderate or severe retinopathy) 69.2 % vs 31.7 %, respectively, p < 0.005 Pc = 0.025). Similar results were also found in a second group of 74 patients who were analysed in the same way. Hence, the failure of some investigators to confirm the association between TCR-Cbeta and Type I diabetes may be due to heterogeneity in the patient populations being studied.

引用

页码：929 / 933

页数：5

共 26 条

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