ADRIAMYCIN RESISTANCE IN CHARACTERIZED BY ULTRASTRUCTURAL-CHANGES IN HUMAN LEUKEMIC K562 CELLS-INVITRO

被引：10

作者：

BOBICHON, H

OKIEMI, MG

BROGLIO, C

PLOTON, D

DUFER, J

机构：

[1] HOP MAISON BLANCHE,INSERM,U314,F-51092 REIMS,FRANCE

[2] INST JEAN GODINOT,F-51056 REIMS,FRANCE

来源：

BIOLOGY OF THE CELL | 1992年 / 74卷 / 03期

关键词：

ADRIAMYCIN-RESISTANCE; K562; CELLS; ULTRASTRUCTURE; NUCLEUS;

D O I：

10.1016/0248-4900(92)90040-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562-resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.

引用

页码：287 / 297

页数：11

共 28 条

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