EXPRESSION OF HUMAN CHORIONIC-GONADOTROPIN ALPHA-SUBUNIT AND BETA-SUBUNIT IS DEPRESSED IN TROPHOBLAST FROM PREGNANCIES WITH EARLY EMBRYONIC FAILURE

被引：18

作者：

HENDERSON, DJ

BENNETT, PR

MOORE, GE

机构：

[1] Action Research Laboratory for the Molecular Biology of Fetal Development, Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, University of London, Queen Charlotte's and Chelsea Hospital

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 10期

关键词：

EARLY EMBRYONIC FAILURE; MESSENGER RNA EXPRESSION; PLACENTAL PROTEINS; TROPHOBLAST;

D O I：

10.1093/oxfordjournals.humrep.a137597

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The expression of the placental proteins human chorionic gonadotrophin alpha (HCGalpha), beta (HCGbeta) and human placental lactogen (HPL) was examined in trophoblast from human normal pregnancy and early embryonic failure (EEF) using Northern blot analysis. Trophoblast from EEF expressed significantly depressed levels of HCGalpha (P < 0.05) and HCGbeta (P < 0.01) when compared to normal pregnancy. Levels of expression of HPL in EEF were not significantly different to those from normal pregnancy. The gestational ages of the two groups were not significantly different. Immunocytochemistry on paraffin-fixed tissue sections supported these data and showed that mRNA levels reflected protein production of HCG within the tissue. It appears from these data that the depressed level of HCG found in the serum of women with early pregnancy failure is not solely a consequence of diminished placentation in these pregnancies, or placental necrosis, but that the genes of the alpha and beta HCG subunits are down-regulated. This study further suggests that there are two subsets of women with early pregnancy failure; those with apparently normal levels of placental proteins, and those with severely depressed levels. It would seem likely that these two groups have different aetiologies.

引用

页码：1474 / 1478

页数：5

共 23 条

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