EFFECTS OF UNOPPOSED CONJUGATED EQUINE ESTROGEN ON LIPOPROTEIN COMPOSITION AND APOLIPOPROTEIN-E DISTRIBUTION

被引:40
作者
MUESING, RA [1 ]
MILLER, VT [1 ]
LAROSA, JC [1 ]
STOY, DB [1 ]
PHILLIPS, EA [1 ]
机构
[1] GEORGE WASHINGTON UNIV, CTR BIOSTAT, ROCKVILLE, MD 20852 USA
关键词
D O I
10.1210/jc.75.5.1250
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Administration of conjugated equine estrogen to 31 postmenopausal women for 3 months produced 14.6% and 9.4% decreases in low density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (apoB), and 11.5%, 12.7%, and 9.6% increases in high density lipoprotein cholesterol (HDL-C), apoA-I and apoA-II, respectively. Phospholipids of HDL2 and HDL3 were increased 57.9% and 19.3%, respectively, while relatively small increases in cholesterol of the two subfractions were not significant. Compositions of LDL and HDL and its subfractions were altered substantially with estrogen treatment. The proportion of LDL triglyceride to LDL-C was increased. The phospholipid content in both the HDL2 and HDL3 subfractions (compared to cholesterol) was increased significantly (34.8% and 10.7%, respectively), while the triglyceride content was increased only in the HDL2 subfraction (43.6%). Estrogen use also caused a 9.1% reduction in total apoE levels and a redistribution of apoE to the very low density lipoprotein (VLDL) from the LDL plus HDL fraction, resulting in a significant 19.5% decrease in apoE in the LDL plus HDL fraction. Changes in apoE in the VLDL fraction were associated positively with changes in the cholesterol levels of the VLDL fraction and inversely with changes in LDL-C and apoB levels, while changes in apoE in the LDL plus HDL fraction were associated positively with changes in the levels of HDL-C. Thus, estrogen causes alterations in lipoproteins that could potentially affect their metabolism and/or function.
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页码:1250 / 1254
页数:5
相关论文
共 37 条
[1]  
APPLEBAUMBOWDEN D, 1989, J LIPID RES, V30, P1895
[2]   LARGE BUOYANT LDL-LIKE PARTICLES IN HEPATIC LIPASE DEFICIENCY [J].
AUWERX, JH ;
MARZETTA, CA ;
HOKANSON, JE ;
BRUNZELL, JD .
ARTERIOSCLEROSIS, 1989, 9 (03) :319-325
[3]  
BAGDADE JD, 1991, J CLIN ENDOCR METAB, V72, P28328
[4]  
BLUM CB, 1982, J LIPID RES, V23, P1308
[5]   CARDIOVASCULAR MORTALITY AND NONCONTRACEPTIVE USE OF ESTROGEN IN WOMEN - RESULTS FROM THE LIPID RESEARCH CLINICS PROGRAM FOLLOW-UP-STUDY [J].
BUSH, TL ;
BARRETTCONNOR, E ;
COWAN, LD ;
CRIQUI, MH ;
WALLACE, RB ;
SUCHINDRAN, CM ;
TYROLER, HA ;
RIFKIND, BM .
CIRCULATION, 1987, 75 (06) :1102-1109
[6]  
BUSH TL, 1987, MENOPAUSE PHYSL PHAR, P187
[7]   MENOPAUSAL ESTROGEN USE, HIGH-DENSITY LIPOPROTEIN CHOLESTEROL SUBFRACTIONS AND LIVER-FUNCTION [J].
CAULEY, JA ;
LAPORTE, RE ;
KULLER, LH ;
BATES, M ;
SANDLER, RB .
ATHEROSCLEROSIS, 1983, 49 (01) :31-39
[8]   PLASMA TRIGLYCERIDE DETERMINES STRUCTURE-COMPOSITION IN LOW AND HIGH-DENSITY LIPOPROTEINS [J].
DECKELBAUM, RJ ;
GRANOT, E ;
OSCHRY, Y ;
ROSE, L ;
EISENBERG, S .
ARTERIOSCLEROSIS, 1984, 4 (03) :225-231
[9]   HIGH-DENSITY LIPOPROTEIN SUBFRACTIONS DURING ORAL AND CUTANEOUS ADMINISTRATION OF 17-BETA-ESTRADIOL TO MENOPAUSAL WOMEN [J].
FAHRAEUS, L ;
WALLENTIN, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 56 (04) :797-801
[10]   THE EFFECTS OF CONJUGATED EQUINE ESTROGENS WITH AND WITHOUT A CYCLICAL PROGESTOGEN ON LIPOPROTEINS, AND HDL SUBFRACTIONS IN POSTMENOPAUSAL WOMEN [J].
FARISH, E ;
FLETCHER, CD ;
HART, DM ;
TEO, HTHTC ;
ALAZZAWI, F ;
HOWIE, C .
ACTA ENDOCRINOLOGICA, 1986, 113 (01) :123-127