SPONTANEOUS CORNEAL-DYSTROPHY AND GENERALIZED BASEMENT-MEMBRANE CHANGES IN FISCHER-344 RATS

被引：15

作者：

BRUNER, RH

KELLER, WF

STITZEL, KA

SAUERS, LJ

REER, PJ

LONG, PH

BRUCE, RD

ALDEN, CL

机构：

[1] Pathology Associates, Inc., West Chester, Ohio 45069-3866

[2] College of Veterinary Medicine, Michigan State University, East Lansing

[3] The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati

来源：

TOXICOLOGIC PATHOLOGY | 1992年 / 20卷 / 03期

关键词：

RENAL LAMELLAR BODIES; RENAL TUBULAR BASEMENT MEMBRANE DYSTROPHY; VASCULAR BASEMENT MEMBRANE DYSTROPHY; GASTRIC BASEMENT MEMBRANE DYSTROPHY; CORNEOSCLERAL MICROGRANULOMA; MINERALIZATION;

D O I：

10.1177/019262339202000306

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Groups of young, sexually mature Fischer-344 rats (n = 25/sex) obtained from 3 commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocular tissues. Results disclosed a high incidence of corneal basement membrane dystrophy in rats of both sexes from all breeders; however, severity levels were significantly increased in rats obtained from one breeder when compared to others. Furthermore, rats that displayed the most advanced corneal lesions also exhibited more severe basement membrane changes in other organs, especially renal tubules and vascular internal laminae. These findings suggest that both ocular and nonocular dystrophic changes may have been linked through common physiologic (or genetic) mechanisms. Animals that displayed basement membrane lesions were not considered to represent compromised biologic test systems.

引用

页码：357 / 366

页数：10

共 10 条

[1]

Alden C.L., Frith C.H., The urinary system, pp. 315-387, (1990)

[2]

Bellhorn R.W., Korte G.E., Abrutyn D., Spontaneous corneal degeneration in the rat, Lab. Anim. Sci, 38, 1, pp. 46-50, (1988)

[3]

Gibbons J.D., Pratt J.W., P-values: Interpretation and methodology, Am. Stat, 29, pp. 20-25, (1975)

[4]

Losco P.E., Troup C.M., Corneal dystrophy in Fischer 344 rats, Lab. Anim. Sci, 38, 6, pp. 702-710, (1988)

[5]

National Research Council, Guidefor the Care and Use of Laboratory Animals, pp. 23-78, (1978)

[6]

Snedecor G.W., Cochran W.G., Statistical Methods, (1980)

[7]

Stitzel K.A., Bruner R.H., Newman E.A., Reer P.J., Petersen D.W., Alden C.L., Hysell D.K., Spontaneous corneal dystrophy in F344 rats, (1988)

[8]

Whorton J.A., Tilsted, Cloudy corneas (whats your diagnosis?), Lab. Anim, 13, 6, pp. 21-22, (1984)

[9]

Yoshitomi K., Blood and lymphatic vessels, pp. 473-484, (1990)

[10]

Yoshitomi K., Boorman G.A., Eye and associated glands, pp. 239-259, (1990)

← 1 →