NATURE OF ORTHO EFFECT - REACTIVITY CORRELATIONS OF ACIDIC AND ALKALINE HYDROLYSES OF ORTHO-SUBSTITUTED N-METHYLBENZOHYDROXAMIC ACIDS

Rates of acidic and alkaline hydrolyses of a series of ortho-substituted N-methylbenzohydroxamic acids have been determined at moderate acidity and very high basicity. The data are correlated by Taft's ortho polar and steric substituent constants. The results provide support for this method of correlation of quantitative data as well as support for the qualitative picture of ortho-substituent effects as described by McCoy and Riecke. © 1978, American Chemical Society. All rights reserved.