TOTAL SYNTHESIS OF MYO-INOSITOL-1-PHOSPHATE-4,5-PYROPHOSPHATE, A NOVEL 2ND MESSENGER ANALOG, VIA MYO-INOSITOL-1-PHOSPHATE-4,5-BISPHOSPHOROTHIOATE

被引：17

作者：

NOBLE, NJ ^{[1
]}

DUBREUIL, D ^{[1
]}

POTTER, BVL ^{[1
]}

机构：

[1] UNIV BATH, SCH PHARM & PHARMACOL, CLAVERTON DOWN, BATH BA2 7AY, AVON, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80172-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the novel analogues of myo-inositol 1,4,5-trisphosphate, myo-inositol 1-phosphate 4,5-bisphosphorothioate and myo-inositol 1-phosphate 4,5-pyrophosphate is reported; the latter was prepared via desulphurisation and intramolecular coupling.

引用

页码：471 / 476

页数：6

共 31 条

[1] A SIMPLE AND EFFECTIVE CHEMICAL PHOSPHORYLATION PROCEDURE FOR BIOMOLECULES [J].

BANNWARTH, W ;

TRZECIAK, A .

HELVETICA CHIMICA ACTA, 1987, 70 (01) :175-186

[2] A SYNTHESIS OF 1D-MYO-INSITOL AND 1L-MYO-INOSITOL 1,3,4,5-TETRAPHOSPHATE [J].

BAUDIN, G ;

GLANZER, BI ;

SWAMINATHAN, KS ;

VASELLA, A .

HELVETICA CHIMICA ACTA, 1988, 71 (05) :1367-1378

[3]

BERRIDGE MJ, 1987, ANNU REV BIOCHEM, V56, P159, DOI 10.1146/annurev.bi.56.070187.001111

[4] INOSITOL PHOSPHATES AND CELL SIGNALING [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1989, 341 (6239) :197-205

[5]

Briggs AP, 1922, J BIOL CHEM, V53, P13

[6] MYOINOSITOL 1,4,5-TRISPHOSPHOROTHIOATE - A NOVEL ANALOG OF A BIOLOGICAL 2ND MESSENGER [J].

COOKE, AM ;

GIGG, R ;

POTTER, BVL .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (20) :1525-1526

[7] SYNTHESIS OF MYOINOSITOL 1,4-BISPHOSPHATE-5-PHOSPHOROTHIOATE [J].

COOKE, AM ;

NOBLE, NJ ;

PAYNE, S ;

GIGG, R ;

POTTER, BVL .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (05) :269-271

[8] SYNTHESIS OF DL-MYO-INOSITOL 1,4,5-TRISPHOSPHATE [J].

COOKE, AM ;

POTTER, BVL ;

GIGG, R .

TETRAHEDRON LETTERS, 1987, 28 (20) :2305-2308

[9] MYOINOSITOL 1,4,5-TRISPHOSPHOROTHIOATE IS A POTENT COMPETITIVE INHIBITOR OF HUMAN-ERYTHROCYTE 5-PHOSPHATASE [J].

COOKE, AM ;

NAHORSKI, SR ;

POTTER, BVL .

FEBS LETTERS, 1989, 242 (02) :373-377

[10]

DESAI T, 1992, UNPUB CARB RES

← 1 2 3 4 →