HEPATOBILIARY AND RENAL EXCRETION IN MICE OF CHARGED AND NEUTRAL GADOLINIUM COMPLEXES OF CYCLIC TETRA-AZA-PHOSPHINIC AND CARBOXYLIC-ACIDS

被引：51

作者：

HARRISON, A

WALKER, CA

PEREIRA, KA

PARKER, D

ROYLE, L

PULUKKODY, K

NORMAN, TJ

机构：

[1] Medical Research Council, Radiobiology Unit, Chilton

[2] Department of Chemistry, University of Durham, Durham, DH1 3LE, South Road

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 06期

关键词：

GADOLINIUM; MRI CONTRAST AGENTS; CYCLIC LIGANDS; BIODISTRIBUTION; HEPATOBILIARY;

D O I：

10.1016/0730-725X(93)90194-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tissue distribution of 21 new Gd-157/153 complexes was measured at 5 min and 24 hr after an intravenous injection into mice. A complex was judged to be stable in vivo when the percentage of Gd-153 retained in the liver and skeleton at 24 hr was comparable with that of Gd-153(DOTA)-. Complexes varied in net charge and lipophilicity and 20 were phosphinic or carboxylic acid derivatives of tetra-aza-cyclo-dodecane. Three anionic, lipophilic complexes were cleared predominantly by the hepato-biliary pathway and were stable in vivo. The remaining 18 complexes were cleared mainly by the kidneys. Of these 18, 1 anionic, 8 neutral, and 3 cationic complexes were stable in vivo. These findings augur well for the future of hepato-biliary and general purpose Gd contrast enhancing agents for MRI.

引用

页码：761 / 770

页数：10

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