Current control methods are not effective in eliminating various mastitis pathogens, and antimicrobial therapy introduces some risk of contaminating dairy products with antibiotic residues. Individuals involved in animal agriculture are sensitive to their responsibility to prevent antibiotic residues from entering the food chain. The ability to understand and perform the appropriate screening systems for determining the residue status of an individual animal, bulk tank, or tanker truck sample provides an opportunity to practice residue management and enhance the quality of dairy products available to the consumer.