MULTIPLE GENETIC EVENTS INVOLVING RBI GENE DELETION AND AMPLIFICATION OF CHROMOSOME-21 IN A CASE OF ACUTE LYMPHOCYTIC-LEUKEMIA

被引：4

作者：

LIU, Y

SODERHALL, S

HEYMAN, M

GRANDER, D

BRONDUMNIELSEN, K

EINHORN, S

机构：

[1] KAROLINSKA HOSP,RADIUM HEMMET,DIV EXPTL ONCOL,S-10401 STOCKHOLM,SWEDEN

[2] KAROLINSKA HOSP,DEPT PEDIAT,S-10401 STOCKHOLM 60,SWEDEN

[3] ODENSE UNIV,DEPT MED GENET,DK-5230 ODENSE,DENMARK

来源：

GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 01期

关键词：

D O I：

10.1002/gcc.2870090113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with acute lymphocytic leukemia was found to have a hyperdiploid karyotYpe, characterized by hexasomy 21 and del(7)(p15). It was shown that the four extra copies of chromosome 21 were all derived from only one of the homologous chromosomes. Molecular analysis showed that the patient had a deletion of both alleles of the retinoblastoma (RBI) gene. These results suggest that multiple events, including loss of RBI gene function and amplification of a key gene(s) on chromosome 21, have contributed to the leukemic transformation. (C) 1994 Wiley-Liss, Inc.

引用

页码：72 / 75

页数：4

共 20 条

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