MUTUAL ANTAGONISM OF BEHAVIORAL-EFFECTS OF TRH AND THIOBARBITURATE ON AN OPERANT TASK IN RHESUS-MONKEYS

被引：2

作者：

KRAEMER, GW ^{[1
]}

KLOPF, FH ^{[1
]}

MCKINNEY, WT ^{[1
]}

机构：

[1] UNIV WISCONSIN,RES INST,MADISON,WI 53706

来源：

PSYCHOPHARMACOLOGY | 1979年 / 61卷 / 01期

关键词：

Rate of responding; Rhesus monkeys; Thiobarbiturate; Thyrotropin releasing hormone;

D O I：

10.1007/BF00426819

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Similar excitatory or depressant response rate dependent effects on monkeys responding on a variable interval reinforcement schedule were observed following intravenous administration of either thyrotropin releasing hormone (TRH) or thiobarbiturate. However, these agents were mutally antagonistic when given together even though the response rate altering effects of each agent were in the same direction. These findings establish an additional behavioral effect of exogenously administered TRH in primates and suggest that barbiturates might alter behavior in part through an interaction with brain TRH receptive mechanisms. © 1979 Springer-Verlag.

引用

页码：103 / 104

页数：2

共 4 条

[1]

BREESE GR, 1975, J PHARMACOL EXP THER, V193, P11

[2] EFFECTS OF THYROTROPIN-RELEASING-HORMONE (TRH) MICROINJECTED INTO VARIOUS BRAIN AREAS OF CONSCIOUS AND PENTOBARBITAL-PRETREATED RABBITS [J].