ABOUT THE RELATIONSHIP BETWEEN ADRENAL-CORTEX AND THYROID-GLAND OF RATS (SHIFT-EFFECT)

In the present paper the inverse quantitative relationships between the thyrotropical system and the adrenocorticotropical system should be demonstrated under different acute experimental conditions by caryometric investigations. In stimulating the adrenal cortex system by a single injection of 0.2 ml saline solution (0.9%)/rat the nuclear sizes of the thyroid follicular cells decreased time-dependent whereas the nuclear parameters of adrenal cortex fasciculata cells increased. In inhibiting the adrenal cortex system and stimulating the thyrotropical system by a single injection of 50 μg TRH/rat the thyroid nuclear values increased time-dependent biphasically and the adrenal cortex parameters decreased correspondingly. The inverse relationships of the histometric parameters of both endocrine organs proved to be highly significant (p≤0.001). The mathematical relations could be expressed by the straight line y = 63.76 - 1.05 x.