STEREOCONTROL IN THE INTRAMOLECULAR NITRONE CYCLOADDITION TO VINYL SULFUR DERIVATIVES

被引:7
作者
ANNUNZIATA, R [1 ]
CINQUINI, M [1 ]
COZZI, F [1 ]
GIARONI, P [1 ]
RAIMONDI, L [1 ]
机构
[1] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY
关键词
D O I
10.1016/S0957-4166(00)86330-2
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The intramolecular cycloaddition to vinyl sulphur derivatives of a series of nitrones featuring an alkyl or alkoxy substituted α-stereocenter on the tether connecting dipole and dipolarophile occurs in a completely stereoselective fashion to give 3′,3-anti configurated products. The synthetic potentialities of this reaction is illustrated by the synthesis of a precursor of (d)-biotin. © 1990.
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页码:251 / 264
页数:14
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