ANTIBACTERIAL ACTIVITY OF FLUOROQUINOLONES IN COMBINATION WITH ZIDOVUDINE

被引：15

作者：

LEWIN, CS

ALLEN, RA

AMYES, SGB

机构：

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1990年 / 33卷 / 02期

关键词：

D O I：

10.1099/00222615-33-2-127

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or Pseudomonas aeruginosa. Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.

引用

页码：127 / 131

页数：5

共 17 条

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[2]

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