EFFECTS OF CENTROPHENOXINE ON THE MONO-VALENT ELECTROLYTE CONTENTS OF THE LARGE BRAIN CORTICAL-CELLS OF OLD RATS

被引:34
作者
ZSNAGY, I [1 ]
PIERI, C [1 ]
GIULI, C [1 ]
DELMORO, M [1 ]
机构
[1] INST NAZL RIPOSO & CURA ANZIANI,CTR CYTOL,DEPT GERONTOL RES,ANCONA,ITALY
关键词
Centrophenoxine; Ionic composition of nerve cell nuclei; Membrane hypothesis; Membrane response; X-ray microanalysis;
D O I
10.1159/000212326
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The effect of centrophenoxine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased the potassium content in both the nucleus and cytoplasm in terms of dry mass fraction, whereas die sodium concentration remained unchanged. The Na+/K+ratio increased significantly in both cell compartments. The chloride content of the nuclei decreased slightly. If one supposes just 1-2% rehydration of the old cytoplasm, the decrease of the total ionic strength may be of considerable extent, it may even reach the values obtained in young adult animals. The results are interpreted in terms of a recently developed ‘membrane hypothesis’ of aging (Zs.-Nagy: J. theor. Biol., 1978, in press). © 1979 S. Karger AG, Basel.
引用
收藏
页码:94 / 102
页数:9
相关论文
共 44 条
[1]   AGE-DEPENDENT EFFECTS IN ENZYME INDUCTION - BIOCHEMICAL EXPRESSION OF AGING [J].
ADELMAN, RC .
EXPERIMENTAL GERONTOLOGY, 1971, 6 (01) :75-&
[2]  
ADELMAN RC, 1977, S BIOCH AGING SANTA
[3]  
Adelman RC, 1972, ADV GERONTOLOGICAL R, V4, P1
[4]   INCREASE IN MICROVISCOSITY WITH AGING IN PROTOPLAST PLASMALEMMA OF ROSE PETALS [J].
BOROCHOV, A ;
HALEVY, AH ;
SHINITZKY, M .
NATURE, 1976, 263 (5573) :158-159
[5]  
Bourne G H, 1973, Prog Brain Res, V40, P187
[6]   DECREASED PROTEIN-SYNTHESIS BY MICROSOMES ISOLATED FROM SENESCENT RAT-LIVER [J].
BUETOW, DE ;
GANDHI, PS .
EXPERIMENTAL GERONTOLOGY, 1973, 8 (05) :243-249
[7]  
CHEMNITIUS K H, 1970, Experimentelle Pathologie (Jena), V4, P163
[8]   INDUCTION OF MITOSIS IN MATURE NEURONS IN CENTRAL NERVOUS-SYSTEM BY SUSTAINED DEPOLARIZATION [J].
CONE, CD ;
CONE, CM .
SCIENCE, 1976, 192 (4235) :155-158
[9]   CONTACT INHIBITION OF DIVISION - INVOLVEMENT OF ELECTRICAL TRANSMEMBRANE POTENTIAL [J].
CONE, CD ;
TONGIER, M .
JOURNAL OF CELLULAR PHYSIOLOGY, 1973, 82 (03) :373-386
[10]   IONIC REGULATION IN GENETIC TRANSLATION SYSTEMS [J].
DOUZOU, P ;
MAUREL, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (03) :1013-1015