SPIROMETRIC LUNG-FUNCTION - DISTRIBUTION AND DETERMINANTS OF TEST FAILURE IN A YOUNG-ADULT POPULATION

被引:46
作者
NGANGA, LW
ERNST, P
JAAKKOLA, MS
GERARDI, G
HANLEY, JH
BECKLAKE, MR
机构
[1] MCGILL UNIV, DEPT EPIDEMIOL & BIOSTAT, RESP EPIDEMIOL UNIT, 110 PINE AVE W, MONTREAL H3A 1A3, QUEBEC, CANADA
[2] KENYA GOVT MED RES CTR, RESP DIS RES CTR, NAIROBI, KENYA
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1992年 / 145卷 / 01期
关键词
D O I
10.1164/ajrccm/145.1.48
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Spirometric test failure has been defined as failure by a subject to meet the acceptability and/or reproducibility criteria laid down by the American Thoracic Society for measurements derived from forced expiratory maneuvers. The prevalence and determinants of spirometric test failure were examined in 416 men and women aged 20 to 45 yr working in an office environment. In this study population, 11.5% (28 men and 20 women) exhibited test failure for forced expiratory volume in one second (FEV1). The main determinant of test failure in men was bronchial hyperresponsiveness to methacholine challenge (odds ratio 6.7; confidence interval 1.7, 27.1) and in women being a current smoker (odds ratio 4.02; confidence interval 1.13, 14.33). There was also a relationship to eczema in both men and women, but not at a statistically significant level. When FEV1 variability was defined as the difference (in milliliters) between the two best FEV1 values and the results of men and women combined for analysis, significant predicators were a history of eczema, recurrent chest illness in the past 3 yr, and level of bronchial responsiveness to inhaled methacholine. These findings contribute to the gathering evidence that test failure may be of itself an indicator of impaired respiratory health, and its association with bronchial hyperresponsiveness to methacholine in men suggests that in them test failure is related to airway lability, but in women the relationship to smoking suggests an irritative mechanism.
引用
收藏
页码:48 / 52
页数:5
相关论文
共 23 条
  • [1] [Anonymous], 1979, AM REV RESPIR DIS, V119, P831
  • [2] [Anonymous], 1987, AM REV RESPIR DIS, V136, P1285
  • [3] BECKLAKE MR, 1990, BRIT J IND MED, V47, P73
  • [4] CHERRY N, 1976, BRIT J PREV SOC MED, V30, P123
  • [5] CRAPO RO, 1981, AM REV RESPIR DIS, V123, P659
  • [6] THE INFLUENCE OF PSYCHOLOGICAL STATUS ON RESPIRATORY SYMPTOM REPORTING
    DALES, RE
    SPITZER, WO
    SCHECHTER, MT
    SUISSA, S
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (06): : 1459 - 1463
  • [7] DIXON WJ, 1985, BMDP STATISTICAL SOF
  • [8] EISEN EA, 1985, AM REV RESPIR DIS, V132, P120
  • [9] EISEN EA, 1983, AM REV RESPIR DIS, V128, P587
  • [10] SELECTION EFFECTS OF REPEATABILITY CRITERIA APPLIED TO LUNG SPIROMETRY
    EISEN, EA
    ROBINS, JM
    GREAVES, IA
    WEGMAN, DH
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1984, 120 (05) : 734 - 742